Multifunctional Anti-Angiogenic Antibody Therapeutics

Synergys Biotherapeutics is a privately held antibody therapeutics company. Founded in the San Francisco Bay Area, Synergys is pioneering the development of combined vasculogenic mimicry-blocking and anti-angiogenic antibody therapeutics primarily for various solid cancers. Some of the current product candidates could be of utility for ocular and other angiogenesis-related diseases of significant unmet medical needs as well. The Company focuses on in-licensing early stage candidates from external sources for in-house development and for eventual collaboration and partnering with larger organizations for late-stage product development and commercialization.

Selected Company News

November 1, 2021

Synergys announces publication of research results in the international journal CELLS, titled, “Inhibition of Vasculogenic Mimicry and Angiogenesis by an Anti-EGFR IgG1-Human Endostatin-P125A Fusion Protein Reduces Triple Negative Breast Cancer Metastases”.


July 1, 2019

Synergys announces second Phase 1 SBIR funding from NIH for development of vasculogenic mimicry-blocking antibody fusion product for ovarian cancer.

October 17-18, 2017

Dr. Rathin Das, CEO, Synergys, gave a presentation at the BIO Investor Forum in San Francisco, CA.


September 26, 2017

SYNERGYS Announces Phase 1 SBIR Grant Award From National Institutes of Health. Grant from NIH's National Cancer Institute will support development of Vasculogenic Mimicry-blocking Antibody Fusion products for Triple Negative Breast Cancer.


October 2, 2015

Dr. Rathin Das., CEO, Synergys, spoke at the LakePharma Protein Engineering Symposium on A-TAP fusion protein for cancer treatment.


June 30, 2015

Dr. Rathin Das, CEO, Synergys, discussed the status of the development  of A-TAP product candidates at the Bio2Device group meeting at San Jose, CA.


November 10, 2014

Prof. Mark Pegram, MD, Director of the Breast Cancer Treatment Program of Stanford University Cancer Institute, Palo Alto, CA, joined Synergys' Scientific Advisory Board.


April 24, 2013
Established research collaboration with a major US university on the preclinical development of Anti-Ang-1/2 MAb program.

​April 18, 2013
Biologics World Korea, Seoul, Korea
Dr. Elizabeth Song, Advisor, presented the status of the Company’s Anti-Ang-1/2 MAb program at the conference.

February 1, 2013
Biopharm International
Published an article titled “Therapeutic Antibodies in Review”, co-authored by Rathin Das, CEO.



Our Strategy

Synergys is developing first-in-class  antibody fusion biotherapeutics for the treatment of cancer by targeting multiple pathways of tumor neovascularization network. The Company's primary focus is to be a leader in developing vasculogenic mimicry-blocking  antibody therapeutics for cancer and other diseases of unmet medical needs. Recent evidences suggest that in addition to angiogenesis, i.e., the development of new vasculature from pre-existing blood vessels, tumor vasculature may also be assembled through the formation and lining of vascular channels by tumor cells themselves, a process termed ‘vasculogenic mimicry’ (VM) (“Tumor’s DIY Blood Vessels”, Science 352: 1381-1383, 2016). VM is a property shared by many tumors which also correlates with tumor aggressiveness, metastasis and resistance to therapy, and may explain the cause for the limited efficacy and tumor resistance of the currently used anti-angiogenic drugs such as bevacizumab. Although marketed anti-angiogenic therapeutics generate multibillion US dollars in annual revenue, no drugs are yet available as either for inhibition of VM or for combined inhibition of angiogenesis and VM. Synergys is developing antibody fusion molecules that are both excellent antiangiogenic as well as profound inhibitor of vasculogenic mimicry functionality. They are expected to be used as monotherapy or in combination with currently marketed anti-angiogenic drugs or chemotherapeutic agents.





Contact Information

Synergys Biotherapeutics, Inc.
Rathin C. Das, Ph.D, MBA

Chief Executive Officer
Phone: 925-575-0181​